I-Ceftiofur Hydrochloride(103980-44-5)
Ingcaciso yeMveliso
I-Ceftiofur yi-antibiotic yohlobo lwe-cephalosporin (isizukulwana sesithathu), ilayisensi yokusetyenziswa kunyango lwezilwanyana.Yaqala ukuchazwa ngo-1987.
Ayinyangeki kwi-enzayimu yokuxhathisa amayeza okubulala iintsholongwane i-beta-lactamase, kwaye inomsebenzi ochasene neebhaktheriya ezine-Gram-positive kunye ne-Gram-negative.Iintlobo ze-E. coli ezixhathisayo kwi-ceftiofur ziye zaxelwa.
I-Ceftiofur Hydrochloride yindlela yetyuwa ye-hydrochloride ye-ceftiofur, i-semisynthetic, i-beta-lactamase-stable, i-spectrum ebanzi, isizukulwana sesithathu se-cephalosporin kunye nomsebenzi we-antibacterial.I-Ceftiofur ibophelela kwaye ingasebenzi i-penicillin-binding proteins (PBPs) ebekwe kwi-membrane yangaphakathi yodonga lweseli yebhaktiriya.Ii-PBPs zii-enzymes ezibandakanyekayo kwizigaba zesiphelo zokuhlanganisa udonga lweseli yebhaktiriya kunye nasekulungiseni udonga lweseli ngexesha lokukhula nolwahlulo.Ukungasebenzi kwe-PBPs kuphazamisa ukuxhamla kwe-cross-link of peptidoglycan chain eziyimfuneko kumandla odonga lwe-bacterial cell kunye nokuqina.Oku kubangela ukuba buthathaka kodonga lweeseli zebhaktiriya kwaye kubangela i-cell lysis.
| IZINTO | INGCACISO | IZIPHUMO | |
| Imbonakalo | Mhlophe ukuya kwi-Off-mhlophe crystalline powder | Vumelana | |
| Ukuchongwa | Ixesha lokugcinwa kwencopho yenqununu kwi ichromatogram efunyenwe kunye nesisombululo sovavanyo correspoonds ukuba kwincopho ephambili kwi ichromatogram efunyenwe ngesisombululo sereferensi. | Vumelana | |
| Ukusabela kweChloride | Vumelana | ||
| Ukubonakala kwesisombululo | Ukucaca | Ayinamandla kunoMgangatho weTrubity onguNombolo 1 | <1 |
| Umbala | Akukho mnyama kunesisombululo esisemgangathweni Y9 | <8 | |
| Ukunyibilika | Inyibilika kwi-N, N- Dimethylacetamide, kancinci Inyibilika kwi-5% ye-sodium bicarbonate kunye ne-methanol. | Vumelana | |
| PH | 2.0~3.0 | 2.2 | |
| Umxholo wamanzi | 1.5%~4.0% | 1.6% | |
| Ukujikeleziswa kwamehlo okuthe ngqo | -115 ° ~ -127 ° | -117 ° | |
| Intsimbi enzima | NMT 0.0020% | Vumelana | |
| Intsalela yomlilo | NMT 0.20% | 0.15% | |
| Izinto ezinxulumeneyo | Ukungcola okukhulu | NMT 0.20% | 0.09 |
| Ukungcola okupheleleyo | NMT 1.50% | 0.38 | |
| Izinyibilikisi ezishiyekileyo | I-Ethyl Acetate | NMT 0.5000% | 0 |
| I-THF | NMT 0.0720% | 0.006 | |
| I-acetone | NMT 0.5000% | 0.2739% | |
| Benzeni | NMT 0.0002% | 0.0001 | |
| Isivavanyi | I-Ceftiofur Hydrochloride | NLT 98.0% | 100.4% |
| I-Chloride | 6.0%~6.5% | 6.2% | |
| I-Bacterial Endotoxin | Ngaphantsi kwe-0.20EU/mg | Vumelana | |
| Ubuzali | Iyahambelana novavanyo | Vumelana | |
| Ubungakanani besuntswana | D (0,1) | <1 | 1.8 |
| D (0,5) | <4 | 1.4 | |
| D (0,9) | <7 | 3.7 | |
| D (1,0) | <10 | 4.2 | |
| ISIPHELO | IZIPHUMO ZOMVAVANYO ZIYAQHUBANA NENKCAZO | ||
