I-Tranexamic Acid(1197-18-8)
Ingcaciso yeMveliso
● Tranexamic Acid(1197-18-8)
● Inombolo yeCAS: · 1197-18-8
● I-EINECS No.: 356.2222
● MF: C8H15NO2
● Iphakheji: 25Kg / Drum
● I-Tranexamic acid (TXA) liyeza elisetyenziselwa ukunyanga okanye ukuthintela ukopha kakhulu kwegazi kumonzakalo omkhulu, ukopha kwasemva kokubeleka, utyando, ukususwa kwamazinyo, ukopha, kunye nokuba sexesheni okukhulu.[2][3]Ikwasetyenziselwa i-angioedema yelifa.[2][4]Ithathwa ngomlomo okanye ngesitofu kwi-vein.
Indlela yokwenza
I-Tranexamic acid yi-analog yokwenziwa ye-amino acid lysine.Isebenza njenge-antifibrinolytic ngokubopha ngokuphindaphindiweyo iisayithi ezine ze-lysine receptor kwi-plasminogen.Oku kunciphisa ukuguqulwa kwe-plasminogen kwi-plasmin, ukuthintela ukuthotywa kwe-fibrin kunye nokugcina isakhelo se-matrix ye-fibrin. I-Tranexamic acid inomlinganiselo ophindwe kasibhozo kumsebenzi we-antifibrinolytic we-analogue endala, i-ε-aminocaproic acid. umsebenzi we-plasmin onamandla abuthathaka (IC50 = 87 mM), kwaye inokuthintela indawo esebenzayo ye-urokinase plasminogen activator (uPA) eneenkcukacha eziphezulu (Ki = 2 mM), enye yezona ziphakamileyo phakathi kwazo zonke i-serine proteases.
Imisebenzi ye-Tranexamic acid
I-Tranexamic acid isetyenziswa rhoqo emva kokwenzakala okukhulu.[13]I-Tranexamic acid isetyenziselwa ukuthintela kunye nokunyanga ukulahleka kwegazi kwiimeko ezahlukeneyo, ezifana neenkqubo zamazinyo, ukopha okukhulu kokuya exesheni, kunye notyando olunomngcipheko omkhulu wokulahleka kwegazi.
| Izinto zovavanyo | Iikhrayitheriya ze-Pharmacopeial | Iziphumo zovavanyo | |
| ABAlinganiswa | Imbonakalo: Imhlophe okanye iphantse imhlophe, i-crystalline powder | Umgubo omhlophe wekristale | |
| Ukunyibilika: Inyibilika simahla emanzini nakwi glacial acetic acid, ayinyibiliki kwiacetone nakwi ethanol (96%). | Dlula | ||
| UKUCHAZA | I-Infrared Absorption Spectrophotometry: I-spectrum ye-IR ihambelana ne-Tranexamic acid CRS | Dlula | |
| UVAVANYO | i-pH (2,2.3) | 7.0 〜8.0 | 7.4 |
| Izinto eziNxulumeneyo (HPLC2.2.29) | Ukungcola A≤ 0.1 % | Ayifunyanwa | |
| Ukungcola B≤ 0.2% | 0.03% | ||
| UkungcolaC Ukungcola okungachazwanga≤ 0.10% Ukungcola D Okunye Ukungcola | 0.002% 0.001% Ayifunyanwa | ||
| Isimbuku sobumdaka obungachazwanga≤ 0.2% | 0.003% | ||
| IiHalides Zibonakaliswe njengeChlorides | ≤140ppm | <140ppm | |
| Ilahleko ekomisweni | ≤0.5% | 0.026% | |
| Uthuthu lweSulfate | ≤0.1% | 0.027% | |
| UVAVANYO | Kufuneka ibe ngaphakathi (Yomisiweyo isekwe) 99.0% 〜101.0% | 100.1% | |
