IGliclazide(21187-98-4)
Uluhlu lweeMveliso
IGliclazide sisiyobisi somlomo se-sulfonylurea antidiabetic.Yikristale emhlophe okanye i-crystalline powder, ayinavumba kwaye ayinancasa.
I-Gliclazide sisizukulwana se-2 somlomo we-sulfonylurea ye-hypoglycemic agent enesenzo esinamandla.Indlela yayo iyafana naleyo ye-toluenosulfonylurea, oko kukuthi, ngokukhethayo isebenza kwiiseli ze-pancreatic β ukukhuthaza ukukhuselwa kwe-insulin kunye nokuphucula ukukhutshwa kwe-insulin emva kokutya iswekile, engakwaziyo nje ukuphucula imetabolism yezigulana ezinesifo seswekile, kodwa ikwaphucula okanye ilibazise ukwenzeka kwesifo seswekile. iingxaki zemithambo yeswekile.
I-Gliclazide isetyenziswa ikakhulu kuhlobo lwe-II yesifo seswekile esincinci kunye nesiphakathi kunye nokuqala kwabantu abadala apho ukutya kunye nokulawulwa kwemithambo yodwa kungasebenzi kwaye ngaphandle kokutyekela kwi-ketosis, kwaye ikwaphucula izilonda ze-fundus kunye nokungasebenzi kakuhle kwe-metabolic kunye nemithambo kwizigulana ezinesifo seswekile.
Isicelo
I-Gliclazide isetyenziselwa ukulawula i-hyperglycemia kwi-gliclazide-responsive diabetes mellitus yesifo seswekile esizinzile, esincinci, esingasiyo ketosis, uhlobo lwe-2 yeswekile.Isetyenziswa xa isifo seswekile singenakulawulwa ngolawulo olululo lokutya kunye nokuzilolonga okanye xa unyango lwe-insulin lungafanelekanga.
| Uvavanyo | Iinkcukacha | Iziphumo zohlalutyo |
| Imbonakalo | Umgubo omhlophe okanye phantse omhlophe. | Umgubo omhlophe |
| Ukunyibilika | Ayinyibiliki ngokupheleleyo emanzini;i-soluble ngokukhululekileyo kwi-methylene chloride;i-soluble kancinci kwi-acetone;Inyibilika kancinane kwi-ethanol (96 pesenti). | Uyahlangabezana neemfuno |
| Izaziso | I-infrared absorption spectrum ihambelana naleyo ifunyenwe nge-gliclazide CRS. | Uyahlangabezana neemfuno |
| Ukungcola B (Nge-HPLC) | ≤2ppm | 0.5ppm |
| Iintsimbi ezinzima | ≤10ppm | <10ppm |
| Izinto eziyeleleneyo (Nge-HPLC) | Ukungcola F ≤0.1% | Ayibonwa |
| Ukungcola okungachazwanga ngakunye ≤0.10% | 0.04% | |
| Isimbuku sobumdaka ngaphandle kwe-F ≤0.2% | 0.11% | |
| Ilahleko ekomisweni | ≤0.25% | 0.11% |
| Uthuthu olufakwe emanzini | ≤0.1% | 0.03% |
| Izinyibilikisi ezishiyekileyo (Ngu-GC) | I-Ethyl acetate NMT 2500 ppm | 265ppm |
| N, N-Dimethylformamide NMT 880 ppm | Ayibonwa | |
| Isivavanyi | 99.0-101.0%, kwisiseko esomileyo. | 100.0% |
| Ukuqukumbela | Iziphumo zovavanyo zihambelana ne-EP8. | |
